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GLP-1 receptor agonists were associated with markedly lower risks of major adverse cardiovascular events, progression of kidney disease, venous thromboembolism, and all-cause mortality compared to DPP-4 inhibitor therapy

But it is still unclear how safe semaglutide is for people with cirrhosis or severe liver failure

This is consistent with the fact that this class of drugs produces significant appetite suppression in response to central and peripheral GLP-1 R activation and has been actively used in the treatment of T2DM, obesity, and overweight (Shah and Vella, 2014

Insurance companies have been hesitant to cover the medications when they're prescribed for weight management, which Lasser said could cause problems for WeightWatchers if patients couldn't afford the costly drugs without insurance coverage

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