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Oral spray and sublingual formulations typically require higher nominal doses to approximate injection exposure

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In contrast, tirzepatide, a dual GIPR/GLP-1R agonist, has been approved for the treatment of T2DM and additionally produces significant weight loss ( The reasons why GLP-1, but not GIP, remains insulinotropic in T2DM are still unclear but may be related to the receptors differing signaling profiles (Yabe and Seino, 2011