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To be clear, the only FDA-approved manufacturers of these medications are the companies that created the active pharmaceutical ingredients Novo Nordisk and Eli Lilly, the joint statement read

Over time, the appetite-suppressing effects often become more predictable as the body adapts to the treatment

Pasqualini, R

The combined central effects of caffeine and other psychostimulant components of EDs (e.g., guarana, Yerba mate) can therefore cause thought chasing, restlessness, insomnia, tremors, and even anxiety disorders and seizures [28,29]

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