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LR3 IGF-1 is a modified analog of human IGF-1 with a 13-amino acid extension at the N-terminus and a substitution of Arg at position 3, which significantly reduces its affinity for IGF-binding proteins

10.1016/j.carbpol.2025.123350 48 ChertoffJ

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[1] [4] Cannabis compounds, particularly THC and CBD, are metabolised extensively in the liver via cytochrome P450 enzymes (notably CYP3A4, CYP2C9, and CYP2C19)