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Biological half-life (more accurately called duration of action) measures how long the physiological effect persists after the peptide clears

Common, usually mild: Injection-site reactions (redness, swelling, itching), most frequent with both Mild headache, dizziness, or flushing after injection Initial water retention as IGF-1 rises Transient fatigue in the first 12 weeks Less common, dose-dependent: Carpal tunnel-like wrist symptoms (sign IGF-1 may be too high) Joint discomfort or stiffness Numbness or tingling in extremities Elevated blood glucose (GH antagonizes insulin) The monitoring that matters:IGF-1 (insulin-like growth factor 1, the downstream marker of GH activity) is the lab value that tells you whether youre in a therapeutic range or pushing past it

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Nevertheless, researchers may consider administering the peptide twice daily instead of once daily, considering the short half-life after an infusion

Journal of Clinical Endocrinology & Metabolism , 2006 Demonstrated sustained GH and IGF-1 elevation with CJC-1295