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Identification of NLRP3 Inflammation-Related gene promoter hypomethylation in diabetic retinopathy

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Biochim Biophys Acta 2001;1571 4

The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

A recent meta-analysis found no clinical improvements in metabolic outcomes