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Three GPX4-independent systems, including Ferroptosis suppressor protein 1 (FSP1)/CoQ10, dihydroorotate dehydrogenase (DHODH) and GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH 4 ), has been identified in the last few years [47]

Its 3-letter sequence, Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Asn-His (31 residues as tabulated with N-terminal modification), features a single methionine that analysts should note as a potential oxidation site during method development, alongside multiple basic residues (Arg, Lys, His) that dominate its charge state envelope in positive-mode ESI-MS

NCT06045221

Screening & Eligibility Firstly, individuals complete a virtual intake with a licensed DevotedDOC provider