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Sweden: J Dahlgren, Gteborg

In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]

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Further trials should conduct better randomization and blinding procedures, recruit more participants, and provide adequate reporting

Oral Option: Rybelsus is the only oral GLP-1 medication, ideal for patients who prefer tablets over injections