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ROS are a necessary defense system to combat microbial respiratory infections (Lambeth, 2004), but oxidative stress and the excessive production of ROS by numerous cells including monocytes and macrophages, neutrophils, as well as pulmonary endothelial and epithelial cells play a major role in the development of ARDS and its complications during COVID-19 infections (Meftahi et al., 2021)

Similarly, it has been confirmed in PC-12 cells that berberine exerts a neuroprotective effect by activating the PI3K/AKT signaling pathway and Nrf2/HO-1 antioxidant signaling pathway (Zhang et al., 2017)

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67 SREBPs have been found to show increased activity in Tregs that infiltrate tumors