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Hormonal alterations Since stress has been described as a potential trigger for ME/CFS (422) and cause of symptom flare-ups (423, 424), it is likely that the HPA axis- the neurobiological stress system- may be implicated in ME/CFS (53, 425, 426), as well as abnormalities in growth hormone (GH) secretion and dysfunctional adrenergic metabolism (255)

Furthermore, research was published explaining how human plasma DSIP decreases at the point of sleep regardless of the timing of the sleep, i.e, a persons usual sleep time, or a later sleep time, natural DSIP still decreased

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