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In neuromyelitis optica, pathogenic autoantibodies target AQP4 by binding to orthogonal arrays of particles, thereby disrupting astrocyte function [415, 416]

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Pre-treatment protocol: Combine pre-injection antihistamine (1 hour before) with pre-injection ice (30 to 60 seconds before) and post-injection cold compress (10 to 15 minutes after) for maximum prevention

Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury

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