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Tirzepatide Tirzepatide is a dual GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptor agonist sometimes called a twincretin. GIP is a second gut hormone involved in insulin secretion, fat storage regulation, and energy metabolism

Days 6 to 7: Symptoms typically stabilize or begin improving

10.1111/j.1365-2125.2011.04037.x 25 NachnaniJ

While this leads to effective weight loss, the associated facial changes result from fat reduction and loss of muscle mass