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The addition of nitro groups to specific tyrosine residues (Y198 and Y250) distorts the region HGF uses to dock with c-met, making it unable to activate satellite stem cells

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If a reconstituted vial accidentally freezes, thaw it slowly in the refrigerator (never at room temperature or under warm water), gently swirl to re-mix, and use it immediately rather than re-storing but expect measurably reduced activity compared to a never-frozen control

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As competitors enter the market, costs may shift, so monitoring these changes is a continuous process

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