The research indicates upregulation of p53-pS15 and p16 maintains a persistent senescent microenvironment that promotes cell cycle arrest and apoptosis resistance in keloid fibroblasts, perpetuating pathological scar formation
The exact dosage will depend on clinical response
10.1016/s0928-4257(01)00036-5 118 SikiricP.SeiwerthS.GrabarevicZ.PetekM.RucmanR.TurkovicB.et al (1994)
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Microglial crosstalk with astrocytes and immune cells in amyotrophic lateral sclerosis