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15 In addition, our preliminary findings in a skin permeability test using a 3-dimensional cultured skin model show that at least some of the GSSG in the stratum corneum side penetrates through the epidermal barrier (data not shown)

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Melanotan-2 produces visible skin darkening after 710 days of daily dosing at 0.51.0 mg as melanin accumulates in melanocytes this is a cumulative structural change requiring repeated administration

Pitt B, Filippatos G, Agarwal R et al (2021) Cardiovascular events with finerenone in kidney disease and type 2 diabetes