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The pigment location in the nail plate is used to guide the matrix biopsy and to anticipate postsurgical sequelae, as a biopsy performed on the distal matrix carries a much lower risk of postsurgical dystrophy than a proximal matrix biopsy

This methylation is crucial to regulate gene expression, neurotransmitter synthesis, myelin formation, and the methylation of histones and DNA (70, 77)

Urso K, Martnez-Bujanda JL, del Prado JM

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