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Several factors can deplete hepatic glutathione stores: Chronic alcohol consumption that overwhelms detoxification pathways Acetaminophen overdose or prolonged use of hepatotoxic medications Metabolic dysfunction associated with obesity and insulin resistance Viral hepatitis and chronic inflammatory conditions Age-related decline in antioxidant enzyme production Understanding these mechanisms helps explain why both glutathione and NAC have become subjects of intense clinical research for liver support and repair

L-glycine is another amino acid that enables the formation of the already mentioned glutathione

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Altered glutathione homeostasis and associated redox imbalance may therefore represent potential therapeutic areas for further investigation

doi: 10.1016/j.ebiom.2022.104323 177 Bin-KhattafRMAlonaziMAAl-DbassAMAlmnaizelATAloudahHSSolimanDAet al