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Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity

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5.4 Pharmacological effects of SIN in other diseases SIN has exhibited therapeutic efficacy in various diseases, including colitis (119), atherosclerosis (120), myocardial ischemiareperfusion injury (100), chronic sciatic nerve injury (CCI) (121), renal injury (122), colorectal cancer (123), lung cancer, liver cancer, cervical cancer, bladder cancer, gastric cancer, and renal cancer (93, 124, 125)