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Inject weekly for several weeks until serum cobalamin normalises, then space out

The ED 50 for this effect is 0.25 2.5 ng/mL

Published data document the pharmacokinetic orders of magnitude observed in humans: dose-dependent plasma Cmax, half-life of 5 to 6 hours when complexed with IGFBP-3/ALS, generally satisfactory tolerance with glycemic monitoring (hypoglycemic risk) and ophthalmological surveillance (rare papilledema)

A person with Crohns disease may have trouble absorbing certain vitamins, such as vitamin B12, if they have undergone the removal of part or all of the ileum or if the disease affects their ileum