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Myasoedova VA, Bozzi M, Valerio V, Moschetta D, Massaiu I, Rusconi V, Di Napoli D, Ciccarelli M, Parisi V, Agostoni P et al

These mechanisms contribute to the substantial weight loss observed in clinical trials, with patients in the STEP 1 trial losing an average of 14.9% of body weight (compared to 2.4% with placebo) on the 2.4 mg weekly dose used for obesity management

Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

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