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Relative telomere length and mitochondrial DNA copy number variation with age: association with plasma folate and vitamin B12. Mitochondrion 51 (2020): 79-87.

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So if methylfolate is lacking (perhaps due to the common MTHFR genetic mutation), homocysteine is not converted and may build up to harmful levels

The relationship between calcium intake and edema-, proteinuria-, and hypertension-getosis: an hypothesis