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It is a prescription medicine with a defined role in diabetes and obesity care, it can help with glycaemic control and weight reduction, but it can also cause nausea, vomiting, constipation and other gastrointestinal side effects

Similar findings were reported in a 2025 real-world analysis of over ten thousand patients: tirzepatide lowered HbA1c by 1.3% and body weight by 10.2 kg, compared with 0.9% and 6.1 kg with semaglutide after 12 months [7]

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TMAO is toxic to the kidney and has been shown to have severe implications in the progression of many diseases such as cardiovascular diseases, heart failure, kidney disease, metabolic syndrome, neurological diseases, and some cancers

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