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On the other hand, additional studies in ghrelin-producing cell lines have demonstrated ghrelin release in response to monosodium glutamate and L-alanine through these receptors

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Consistent with previous reports 26 , the diabetic rats displayed marked increases in fasting blood glucose, HbA1c, TAG, and LDL cholesterol, accompanied by reduced HDL cholesterol, confirming a dyslipidemic and hyperglycemic state

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Fatty acid accumulation causes insulin resistance through insulin signaling cascades, which counteracts increased glucose uptake and glycolysis 46