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Diet and exercise must be considered as the first line of treatment, however if they fail to correct metabolic signalling, IGF-1 therapy seems to be promising at metabolic harmonisation

Main Research Findings 1) Results of this study reported that IGF-1 DES led to excitatory transmission in the CA1 region of the rat hippocampus and enhancement of fEPSP slopes in a dose-dependent manner

This is suggestive of potential and likely transient interactions between acidic Glu1273 and the sequentially nearest (i-4) basic residue Lys1269

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