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AOD-9604 holds FDA GRAS (Generally Recognized As Safe) status for food use a rare regulatory distinction among research peptides that reflects an established safety profile across multiple toxicology studies and chronic-exposure models

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An altered intestinal barrier function can also be a result of host physiological factors (e.g., bile acids) and environmental factors (e.g., dietary components) and is not necessarily deleterious, leading to a disease phenotype