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They also play important roles in many other (non-gender-specific) physiological processes, including cardiovascular and nervous systems function ( The two major biologically active estrogens in non-pregnant humans are estrone (E1) and estradiol (E2)

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4.4.1 Betulin-based NLCs Nanostructured lipid carriers (NLCs), composed of a mixture of solid and liquid lipids, have been developed as next-generation delivery systems offering higher drug-loading capacity, enhanced stability, and strong occlusion effects that improve dermal penetration [124]