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Particularly among patients with psychiatric comorbidities, adverse neuropsychiatric outcomes such as anxiety and mood changes have been observed, especially with cannabinoid receptor 1 antagonists and stimulants [26, 27]

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Treatment duration varies depending on individual needs

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If you have optimized every aspect of technique, escalated to the highest recommended sublingual dose, and still see inadequate results after 8-12 weeks, the delivery method may be the limiting factor