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Akkermansia muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes

Scientists working on the compound wanted to "study its effects on pigmentation and appetite regulation." Essentially, the chemical is meant to simulate MSH (melanocyte-stimulate hormone)

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The STEP-1 trial that established semaglutide for weight management capped doses at 2.4 mg weekly and produced 14.9% mean body-weight loss over 68 weeks (Wilding et al., 2021)