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Additionally, a 2025 retrospective study on chronic knee pain showed that 14 out of 16 patients reported significant relief lasting 612 months, and a 2024 pilot study on interstitial cystitis achieved symptom resolution in 10 out of 12 subjects

People with dietary restrictions, such as vegans and vegetarians, who may not get sufficient B12 from their diet, or those with absorption issues, like those with pernicious anemia or gastrointestinal disorders, also often qualify