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Much of this effect was found to be driven by D5 signaling in DCs, which increased the frequency of inflammatory CD4 + T-cells in the CNS and drove inflammation by blocking signal transducer and activator of transcription and inducing the activity of IL-12 and IL-23 in T-cells (Prado et al., 2018)

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NHS prescriptions offer the most affordable route at 9.90 per item in England (or free with exemptions), whilst private treatment can exceed 3,000 annually