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In this case, it mimics the GLP-1 hormone that targets areas of the brain involved in regulating appetite and food intake

doi: 10.1016/j.mce.2019.110631 85 GhaibourKSchuhMSouali-CrespoSChambonCCharlotARizkJet al

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Motor neuron disease systematic multi-arm adaptive randomised trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and increases peripheral insulin sensitivity, and may reduce appetite by raising glucagon like peptide-1 levels