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In the STEP trials, which tested semaglutide 2.4 mg for weight management, nausea affected 43.9% of participants compared to 16.1% on placebo

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This effect involves upregulation of integrin receptors, particularly alpha5beta1 and alpha2beta1, which mediate keratinocyte attachment to provisional matrix proteins including fibronectin and collagen

If you have a sensitive stomach, you can take them with a small snack

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