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For example, mapping the interactomes of HSP70 and HSP90 has clarified that these proteins not only ensure correct folding but also influence autophagic decision-making and UPS performance, 548,549 highlighting their integrative role in proteostasis governance

Due to their role in oxygen transport, RBCs have evolved a relatively simple proteome

Zhang XQ, Zhang G, Zhang H, Karin M, Bai H, Cai DS

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It was recently pointed out that the anti-oncogene BRCA1-Associated Protein 1 (BAP1) deubiquitinates the H2Aub portion of the SLC7A11 gene promoter and represses SLC7A11 expression, thereby limiting Cys uptake and increasing ferroptosis sensitivity