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Example-12: Preparation of compound of formula-17 DMAP (77.69 gm) and t-butanol (400 ml) were added to a mixture of toluene (3600 ml) and compound of formula-16 (400 gm) at 25-30C and stirred the reaction mixture for 30 min at the same temperature

These patients may require combination therapy with basal insulin or other agents targeting different pathophysiological mechanisms