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Silva, T

SP signal peptide

Lakhal-Littleton S, Crosby A, Frise MC, Mohammad G, Carr CA, Loick PAM, et al

Although the PERK pathway is the principal UPR sensor related to mitochondrial homeostasis, under some conditions of renal disease, the transcription factor ATF6 decreases the expression of PPAR and downregulates the expression of genes related to mitochondrial beta-oxidation, leading to fibrosis (Casas-Martinez et al

The study demonstrated that kaempferol led to significant repair of liver damage, reduction in serum levels of HA, LN, AST, and ALT, decreased collagen deposition, and downregulation of COL11 and -SMA RNA and protein expression