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While all GLP-1 agonists work by mimicking the incretin hormone GLP-1 to stimulate insulin secretion and slow gastric emptying, each drug differs slightly in its formulation, dosage frequency, and specific mechanisms of action

Results from meta-regression analysis showed that the duration of treatment accounted for 41.01% of heterogeneity among studies

Meanwhile, orforgliprons oral GLP-1 format may finally unlock mass adoption by removing injection-related barriers, while Survodutide, CT-388, and Pemvidutide demonstrate that dual and triple agonists, with novel combinations of GLP-1, glucagon, and GIP, can outperform monotherapies in both efficacy and metabolic breadth

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