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Transparently, my dad had open-heart surgery about 10 years ago, and I want to be as proactive as possible about my cardiovascular health

The foundational preclinical study was published by Neelakantan et al

Oxyntomodulin, produced by the L-cells in the distal small intestine, binds to both glucagon receptor and GLP-1 receptor and is structurally very similar to glucagon

I mean, people are using medication that reduces the speed at which nutrients and energy are made available to the body while also reducing overall intake and they are surprised about being fatigued

Given that brain inflammation is an immune response mediated by microglia and astrocytes, it has been postulated that the anti-neuroinflammatory effect of GLP-1RAs could be in part due to their inhibitory action on astrocytes and microglia via the activation of cAMP/PKA signaling [82]