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When cells respond to oxidative stress, large amounts of highly reactive and toxic ROS are produced and lead to adverse changes in cellular components such as proteins, lipids, and DNA damage [41].Cell membrane is particularly vulnerable to ROS damage due to its high polyunsaturated fatty acids (PUFA), called lipid peroxidation, which is the most significant feature of ferroptosis
Disease-modifying and symptomatic treatment is complex, difficult and not standardized
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Notably, catalase and superoxide dismutase, acting in concert with glutathione peroxidase constitute the major defense or primary antioxidant enzymes against superoxide radicals (DeKosky et al
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