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Mater Sci Eng C 114:111034

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While Dihexa is generally well-tolerated, some users report: These are typically dose-dependent and resolve with adjustment

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Replacement of L-amino acids with D-amino acids, methylation of the N-terminus, and use of cyclic residues can improve peptide stability to an extent, along with formulation approaches including enteric coating and inclusion of excipients that change local pH away from the enzyme peptidase activity