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Ipamorelin, a selective pentapeptide growth hormone secretagogue derived from GHRP-1, was originally developed by Novo Nordisk and represents the first highly selective growth hormone-releasing peptide with minimal effects on other pituitary hormones

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Given the importance of GRK levels to morphine-dependent regulation of receptors in model cell systems, it is conceivable that alterations in GRK2 expression or subcellular distribution following chronic opioid treatment could contribute to significant reprogramming of opioid regulatory responses