Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells
Although the enrichment of L-cells by pharmacological agents can be a novel approach for improving insulin secretion, glucose tolerance and the treatment of T2DM, more research for the specific differentiation of L-cells and the translation of in vitro and animal data to humans, are needed for the success of this approach
Disclosures Mojca Jensterle has given lectures, received honoraria, participated in conferences and advisory boards sponsored by pharmaceutical companies including Amgen, Eli Lilly, Merck Sharp & Dohme, Novo Nordisk, Novartis and Servier
This hormone signals to the brain, telling you to stop eating because youre satisfied
BPC-157 studies in rodent models have used concentrations ranging widely from nanomolar to micromolar in cell culture, and from 10mcg/kg to 10mg/kg in animal models depending on the study endpoint [1,2]
