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Rather than blocking a single cytokine outright, many peptides modulate upstream regulatory pathways

As brain endothelial cells are only about 200 nm thick, 14 membrane protein sorting must be very efficient

Thus, disturbances in mitochondrial ICS biosynthesis could contribute to failures in the supply of energy (which might result in cell death) or to cancer, since genomic instability is considered as a hallmark of cancer and a driver of neoplastic transformation processes

Lancet 373 , 473481 (2009)

Please note that our peptides, including FOXO4-DRI, are not designed for human consumption or clinical application