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H (400 MHz, MeOD): 7.947.85 (3 H, m, ArH), 7.857.72 (12 H, m, ArH), 4.62 (1 H, dd, J = 9.1, 4.9 Hz, H-4), 4.05 (1H, t, J = 6.4 Hz, H-1), 3.89 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.85 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.513.37 (2 H, m, PCH 2 ), 3.25 (1 H, d, J = 14.7 Hz, H-7 A or B ), 3.192 (1 H, d, J = 14.7 Hz, H-7 A or B ), 3.188 (2 H, d, J = 6.5 Hz, H-8), 3.10 (1 H, dd, J = 14.0, 4.9 Hz, H-5 A or B ), 2.84 (1 H, dd, J = 14.0, 9.1 Hz, H-5 A or B ), 2.59 (2 H, t, J = 7.1 Hz, H-3), 2.352.22 (1 H, m, H-2 A or B ), 2.222.11 (1 H, m, H-2 A or B ),1.761.65 (2 H, m, CH 2 ), 1.661.50 (4 H, m, CH 2 )

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Therefore, Hgc1 maintains CDC42-GTP activity in the apical zone by inhibiting GAP-driven GTP hydrolysis [81]

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A toxic intermediate compound up to 30 times more harmful than ethanol itself