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In conditions such as pancreatic ductal adenocarcinoma and heart failure, the effects caused by changes in lactate levels cannot be reversed merely by manipulating P300 [33, 41]

As a result, potential safety concerns might arise in everyday clinical practice that were not evident during the more controlled and structured environment of clinical trial evaluations [Reference Paludetto, Olivier-Abbal and Montastruc28]

HR, 0.76 [95% CI, 0.670.88

Participants who prematurely discontinued semaglutide were switched to another glucose-lowering drug at the investigators discretion