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These preclinical results prompted off-label use in humans, primarily through compounding pharmacies and peptide clinics

Metformin was introduced to treat T2DM in France in 1958 and now after over 60 years is used on a daily basis by over 150 million people (4)

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[3,4] This leads to far smaller doses required for similar or better glycemic results, needing fewer capsules and reduced risk of gastrointestinal issues

Genotype report: Additional MTHFR variants Additional variants to check that decrease MTHFR enzyme function: Access this content: An active subscription is required to access this content