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The STEP UP trial, published in The Lancet Diabetes & Endocrinology in September 2025, showed 18.7% average weight loss at 72 weeks compared to 15.6% at the standard 2.4 mg dose

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Arginine is a conditionally essential basic amino acid involved primarily in urea metabolism and excretion, as well as in DNA synthesis and protein production

Anorectal discomfort is common, but often leads to delayed consultations due to fear or shame

compared the impact of single versus combined treatment with high-intensity interval exercise (HIIE) and GLP-1RA semaglutide on cognitive dysfunction in obese diabetic mice (50)