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They also act on appetite centres in the brain, particularly the hypothalamus, to reduce hunger signals and food cravings

doi: 10.1016/j.arr.2021.101543

On the other hand, prolonged (16 h) stimulation with GLP-1 was shown to promote Hypoxia-Inducible Factor 1 (HIF-1) activity via induction of the mammalian Target of Rapamycin (mTOR) 16

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Summary: Ozempic does not affect Botox through direct pharmacological interaction, as these medications work through completely separate biological mechanisms with no known contraindications