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While much is currently known about APAP hepatotoxicity regarding its epidemiology, risk factors, pharmacology and toxicology, diagnostics and treatment modalities, there remains a plethora of scientific questions that should be answered in order to improve the understanding of molecular and sub-molecular relationships and pathways that may offer new therapeutics to tackle this curable yet potentially devastating event

Klarl BA, Lang PA, Kempe DS, Niemoeller OM, Akel A, Sobiesiak M, et al

(1 January 2015)

10.1016/j.jpsychires.2006.07.013 J Psychiatr Res

Unlike the other common amino acids, rotation about the C-N bond in proline is not possible due to the structural constraint of the five-membered ring