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Dihexa has not been tested in mood paradigms Conclusion# Dihexa and PE-22-28 both represent genuinely novel approaches to nootropic pharmacology, targeting pathways (HGF/c-Met and TREK-1, respectively) that are largely unexplored in cognitive enhancement research

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Modern therapeutic strategies target inflammatory mediators including TNF-, IL-17, IL-23, and intracellular pathways such as NF-B and JAK/STAT