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Similarly, a randomised control trial in older adults with median age 73 years reported that supplementation of 500 mcg vitamin B12, 400 mcg folic acid and 15 mcg vitamin D3 for two years resulted in an average reduction of homocysteine by approximately -4.2 micro mol/L compared to the placebo group (De Koning et al, 2016)

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Institutional review board statement The study was conducted following the Good Clinical Practice standards and the Helsinki Declaration, and approved by the Ethical Committee of the University of Cagliari (protocol PG/2018/16313)

(2017) 152:190114.e3